AUTOTAC-mediated targeted degradation of transthyretin aggregates ameliorates hereditary transthyretin amyloidosis
Hee Yeon Kim, Daniel Youngjae Park, Eun Hye Cho, Yeon Sung Son, Sung Hyun Kim, Ki Woon Sung, Helena Sofia Martins, Maria João Saraiva, Maria Rosário Almeida, Chang Hoon Ji, Yong Tae Kwon
This study identifies the N-degron pathway's role in lysosomal degradation of TTRV30M aggregates and demonstrates the therapeutic potential of AUTOTAC-based degraders for hATTR.
bioRxiv · Feb 24, 2026 · PreprintCell Biology