NSUN2-dependent 5-methylcytosine Modification Regulates Influenza A virus Gene Expression and Genomic Packaging
Jing Hu, Shengqiang Jiang, Wanling You, Ruiwei Hao, Jianchao Li, Shujuan Gong, Xiao Xiao, Haiyan Zhao, Long Liu, Hongying Chen
This study shows that NSUN2-dependent m5C modifications on influenza A virus RNA are essential for proper viral particle assembly and pathogenicity, suggesting m5C depletion could attenuate IAV strains.
bioRxiv · Nov 26, 2025 · PreprintMicrobiology