Jiyeon K. Denninger

This study shows that adult hippocampal NSPCs secrete VEGF, which supports and protects hippocampal function independently of neurogenesis.

This study compares bulk and single-cell RNAseq for identifying differentially expressed genes in adult hippocampal NSCs, finding single-cell methods miss high-fold-change genes but can be optimized for in vivo use.

This study shows that neural stem cells in the adult mouse hippocampus use VEGF to maintain their connection to vasculature and regulate their own motility and quiescence through internal signaling.

The paper compares in vitro and in vivo transcriptomic and proteomic profiles of adult hippocampal NSPCs, finding discrepancies in secreted protein abundance and gene expression.