Sneider Alexander Gutierrez Guarnizo

This study uses bulk RNA sequencing in a porcine model of neurocysticercosis to identify transcriptional signatures associated with viable parasite persistence and post-treatment lesion disruption.

This study shows that maternal Trypanosoma cruzi infection causes significant placental remodeling and systemic changes, regardless of whether the infection is transmitted to the fetus, and identifies potential biomarkers for prenatal monitoring.

The paper sequenced clinical T. cruzi isolates, finding genomic instability and a unique antigen repertoire absent in lab-adapted strains.

The paper presents a high-quality whole genome assembly of a Trypanosoma cruzi hybrid strain using nanopore sequencing, revealing insights into genomic structure and surface protein diversification.