Kimberlee P. Giffen

This study compares gene expression in zebrafish and mouse inner ear hair cells to identify molecular differences underlying their physiological specializations.

The paper uses in silico transcriptomics to identify FDA-approved drugs and pathways that protect against cisplatin-induced hearing loss, validating niclosamide as a potential otoprotectant.

This study shows that LBH is essential for maintaining cochlear hair cells and stereocilia bundles, with its loss causing progressive hearing loss and OHC degeneration.