Jian Zuo

The paper identifies the kinocilium as a unique organelle with molecular features of both primary and motile cilia, showing it generates force in the hair bundle.

This study identifies oseltamivir as a drug that protects against hearing loss in mice caused by cisplatin and noise exposure.

This paper identifies EGFR inhibitors as potential therapeutics for noise-induced hearing loss using in silico transcriptome-based drug screening and experimental validation in zebrafish and mouse models.

This paper shows that knocking out KSR1 in mice protects against cisplatin- and noise-induced hearing loss by inhibiting the MAPK pathway.

The paper uses optogenetics to study the role of supporting cells in force transmission to and from outer hair cells in the mouse cochlea, finding that hyperpolarizing these cells suppresses cochlear amplification and alters mechanical responses.

The paper uses in silico transcriptomics to identify FDA-approved drugs and pathways that protect against cisplatin-induced hearing loss, validating niclosamide as a potential otoprotectant.