Zhao Zhang

This paper demonstrates a CRISPR-based method to construct haplotype-resolved assemblies of targeted genomic regions, achieving comparable accuracy with reduced cost and complexity.

Candidate Explorer identifies causative mutations for immune phenotypes by integrating multiple data features into a score, improving mutation-phenotype association verification in mice.

This paper develops CRISPR systems to target and deplete an oncogenic KRAS mutant allele, leading to tumor regression in vitro and in vivo.