Author

Keshav GC

University of MichiganORCID 0000-0001-9348-5358Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Alice TelesnitskyiD· 2 shared Cleo BurnettiD· 2 shared Siarhei KharytonchykiD· 2 shared A. Emery· 1 shared K. GopaliD· 1 shared Nathan M. ShereriD· 1 shared Ronald I. SwanstromiD· 1 shared Sydney G. ClarkiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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2 shared papersMicrobiology

Alice TelesnitskyORCID

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2 papers

Recent·Most cited

HIV-1 single transcription start site mutants display complementary replication functions that are restored by reversion

Keshav GC, Szilvia Lesko, A. Emery, Cleo Burnett, K. Gopal, Sydney G. Clark, Ronald I. Swanstrom, Nathan M. Sherer, Alice Telesnitsky, Siarhei Kharytonchyk

This study examines HIV-1 mutants that produce only one transcription start site RNA and finds that they display complementary replication functions restored by reversion.

Journal of Virology · Mar 4, 2025Peer-reviewedMicrobiology

Transcription start site heterogeneity and its role in RNA fate determination distinguish HIV-1 from other retroviruses and are mediated by core promoter elements

Siarhei Kharytonchyk, Cleo Burnett, Keshav GC, Alice Telesnitsky

The paper identifies HIV-1's use of heterogeneous transcription start sites (TSSs) for RNA fate determination, showing it differs from other retroviruses and is mediated by core promoter elements.

Journal of Virology · Sep 8, 2023Peer-reviewedMolecular Biology