Scott A. Barbee

Drosophila FMRP recruits the miRISC to target mRNAs to repress translation

This study shows dFMRP recruits miRISC to repress translation of target mRNAs in Drosophila, independent of deadenylation and requiring AGO1 and GW182.

The KH domains of FMRP differentially regulate neuronal granule formation, dynamics, and function in Drosophila

This study shows that mutations in the KH domains of FMRP impair RNA granule formation and function in Drosophila, linking these defects to FXS pathogenesis.

Drosophila p38 MAPK Interacts with BAG-3/starvin to Regulate Age-dependent Protein Homeostasis

This study investigates how the Drosophila p38 MAPK gene influences age-dependent protein aggregation through its interaction with the Chaperone-Assisted Selective Autophagy complex.

Vps54 regulates lifespan and locomotor behavior in adult Drosophila melanogaster

This study creates a Drosophila model of Vps54 loss-of-function and shows it leads to shortened lifespan, muscle atrophy, and locomotor defects similar to the wobbler mouse.

Vps54 regulates Drosophila neuromuscular junction development and controls postsynaptic density composition via a Rab7-dependent mechanism

This study shows that Vps54 regulates Drosophila neuromuscular junction development and postsynaptic density composition through Rab7-dependent endosomal trafficking.