Kimberly Quililan

This study shows translocations can drive widespread gene expression changes across entire chromosome arms in MCL by altering chromatin organization and regulatory loops.

This study reconstitutes chromatin domains in vitro using S. cerevisiae and shows that nucleosome positioning alone is sufficient for domain formation.

scTAM-seq provides high-confidence single-cell DNA methylation analysis with high throughput, resolving B-cell differentiation dynamics and integrating with protein and mutation data.

The paper analyzes sub-kilobase chromatin topology to show that nano-scale regulatory interactions depend on CTCF but not cohesin, and that cohesin affects longer-range enhancer-promoter interactions.