Author

Alfonso María Valencia

Barcelona Supercomputing CenterORCID 0000-0002-7276-4240Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

A. Marieke OudelaariD· 1 shared Agostina BianchiiD· 1 shared Alastair SmithiD· 1 shared Andrea Rivero· 1 shared Anna OncinsiD· 1 shared Chloe GulliveriD· 1 shared Cristina LópeziD· 1 shared David G. PisanoiD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

A. Marieke OudelaarORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Translocations can drive expression changes of multiple genes in regulons covering entire chromosome arms

Anna Oncins, Roser Zaurín, Houyem Toukabri, Kimberly Quililan, José R Hernández Mora, Magdalena A. Karpińska, Erik Wernersson, Alastair Smith, Agostina Bianchi, Leone Albinati, Luca Cozzuto, Andrea Rivero, Chloe Gulliver, Jessica Velten, Johanna Denkena, , Renée Beekman

This study shows translocations can drive widespread gene expression changes across entire chromosome arms in MCL by altering chromatin organization and regulatory loops.

Nucleic Acids Research · Aug 11, 2025Peer-reviewedCancer Biology

Three-dimensional connectivity and chromatin environment mediate the activation efficiency of mammalian DNA replication origins

Karolina Jodkowska, Véra Pancaldi, Ricardo Almeida, Maria Rigau, Osvaldo Graña‐Castro, José Miguel Fernández-Justel, Sara Rodríguez‐Acebes, Miriam Rubio-Camarillo, Enrique Carrillo de Santa Pau, David G. Pisano, Fátima Al‐Shahrour, Alfonso María Valencia, Marı́a Gómez, Juan Méndez

The paper investigates how 3D chromatin structure and chromatin environment influence DNA replication origin activation efficiency in mouse embryonic stem cells under stress and control conditions.

bioRxiv · May 29, 2019 · PreprintGenomics