Mareike Albert

This study identifies basal fluidization in human neuroepithelia as a tissue-level mechanism driving forebrain expansion, distinct from other great apes and mice.

This study identifies human-specific morphoregulatory signatures in basal radial glia that drive neocortex evolution through comparative chromatin and transcriptional profiling.

The paper compares the roles of canonical and non-canonical PRC1 sub-complexes in neural stem cell regulation during neocortex development, finding canonical PRC1 has a more significant impact.

The paper identifies H3K27me3 regulation of extra-cellular matrix composition in human corticogenesis using Epi-CyTOF and cortical organoids.

This study shows that primate-specific EPIREGULIN expression enhances basal progenitor proliferation in the developing neocortex, contributing to increased brain size across species.

The paper shows H3K9ac increases basal progenitor proliferation and neocortex size by upregulating TRNP1 in evolution.

This study shows that human-specific ARHGAP11B increases proliferative basal radial glia and expands the neocortex in developing ferrets.

The paper identifies human-specific genes preferentially expressed in fetal neocortex progenitors and shows they have distinct cell-type specificity compared to ancestral paralogs.