The paper identifies consistent MYORG downregulation in DMD and LGMD through transcriptomic and proteomic analysis, supporting the repurposing of deoxygalactonojirimycin as a pharmacological chaperone.

DOI 10.64898/2026.06.17.732878

humanbulk RNA-seq

𝕏 PostBluesky

Molecular BiologybioRxivPreprintApr 21, 2026

MYORG and STRADB as Activity-Dependent Therapeutic Targets for Frailty Prevention: Discovery and Cross-Cohort Validation in Aging Skeletal Muscle

Rangaprasad Sarangarajan, Kastoori Iyengar

The paper identifies MYORG and STRADB as activity-dependent biomarkers for muscle health and challenges conventional atrogene paradigms by showing activity confounds age-based signatures in skeletal muscle.

1 citation

humanbulk RNA-seq

𝕏 PostBluesky

Genetic & Genomic MedicinemedRxivPreprintMay 14, 2024

Metabolome-wide association of carotid intima media thickness identifies FDX1 as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations.

Nilanjana Sadhu, Rinkoo Dalan, Pritesh Jain…·John Campbell Chambers

3 citations

humanmetabolomics

𝕏 PostBluesky

NeuroscienceScientific ReportsPeer-reviewedMay 1, 2024

Identification and Validation of N-Acetylputrescine in Combination With Non-Canonical Clinical Features As a Parkinsons Disease Biomarker Panel

Kuan‐Wei Peng, Allison Klotz, Arcan Güven…·Michael A. Kiebish

The paper identifies and validates a biomarker panel combining N-acetylputrescine with clinical features for Parkinson's disease diagnosis, showing high diagnostic accuracy.

10 citations

humanmetabolomics

𝕏 PostBluesky

NeurosciencebioRxivPreprintDec 8, 2018

Multi-OMIC analysis of brain and serum from chronically-stressed mice reveals network disruptions in purine metabolism, fatty acid beta-oxidation, and antioxidant activity that are reversed by antidepressant treatment

Peter J. Hamilton, Emily Y. Chen, Vladimir Tolstikov…·Eric J. Nestler

The paper analyzes multi-omic data from stressed mice to identify molecular disruptions linked to depression and shows antidepressants reverse these changes in specific brain regions.

4 citations

mousemetabolomics

𝕏 PostBluesky