Author

Ana Nicolle Strat

Icahn School of Medicine at Mount SinaiORCID 0000-0001-6499-1518Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:mouse· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Drew D. KiralyiD· 2 shared Nicholas L. Mervosh· 2 shared Preethi S. GanapathyiD· 2 shared Samuel HerbergiD· 2 shared Yutao LiuiD· 2 shared Alexander Kirschner· 1 shared Alison E. PattesoniD· 1 shared Ariela Buxbaum Grice· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersNeuroscience

Drew D. KiralyORCID

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4 papers

Recent·Most cited

Cell BiologybioRxivPreprintOct 28, 2026

Transcriptomic profiling of normal and glaucomatous trabecular meshwork cells in a tissue-like soft ECM environment

Rajanya Ghosh, Rachel Hadvina, Ana Nicolle Strat…·Samuel Herberg

The paper identifies 588 differentially expressed genes in glaucomatous versus normal trabecular meshwork cells cultured in a soft ECM environment, revealing three disease-related programs.

DOI 10.64898/2026.10.26.761819

humanbulk RNA-seq

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NeurosciencebioRxivPreprintJun 20, 2025

Compression injury regulates astrocyte morphology, metabolic function, and extracellular matrix modification in a 3D hydrogel

Ana Nicolle Strat, Suhani Patel, Minh‐Tri Ho Thanh…·Preethi S. Ganapathy

This study investigates how compressive strain affects astrocyte morphology, metabolism, and ECM modification in a 3D hydrogel model of the optic nerve head.

3 citations

mouseexperimental assay

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NeuroscienceBrain, Behavior, and ImmunityPeer-reviewedNov 1, 2023

Acetate supplementation rescues social deficits and alters transcriptional regulation in prefrontal cortex of Shank3 deficient mice

Aya Osman, Nicholas L. Mervosh, Ana Nicolle Strat…·Drew D. Kiraly

The paper shows acetate supplementation improves social deficits and changes gene expression in the prefrontal cortex of Shank3-deficient mice.

50 citations

mousebulk RNA-seq

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NeurosciencebioRxivPreprintDec 8, 2018

Multi-OMIC analysis of brain and serum from chronically-stressed mice reveals network disruptions in purine metabolism, fatty acid beta-oxidation, and antioxidant activity that are reversed by antidepressant treatment

Peter J. Hamilton, Emily Y. Chen, Vladimir Tolstikov…·Eric J. Nestler

The paper analyzes multi-omic data from stressed mice to identify molecular disruptions linked to depression and shows antidepressants reverse these changes in specific brain regions.

4 citations

mousemetabolomics

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