Jaffna Mathiaparanam

Huntingtin and Celsr3 Orchestrate Spontaneous Long-Distance Spinal Cord Regeneration

This study identifies celsr3 and huntingtin as critical for long-range spinal cord regeneration in zebrafish, showing distinct roles in initiating and sustaining axonal growth.

Serotonin neuromodulation directs optic nerve regeneration

The paper identifies serotonin type-1 receptor signaling as a key regulator of early optic nerve regeneration in zebrafish, showing it promotes axonal regrowth but is dispensable during development.

Inhibition of Cxcr4 chemokine receptor signaling improves habituation learning and increases cAMP-PKA signaling in a zebrafish model of Neurofibromatosis type 1

This study shows that inhibiting Cxcr4 signaling improves habituation learning and increases cAMP-PKA signaling in nf1 mutant zebrafish.

Pregnancy-associated plasma protein-aa supports hair cell survival by regulating mitochondrial function

This study identifies Pappaa as a regulator of mitochondrial function and hair cell survival in zebrafish by modulating IGF1 bioavailability and mitochondrial stress responses.