Author

Prajwal Chaitanya Boddu

Yale Cancer CenterORCID 0000-0001-9408-5882Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Manoj M. PillaiiD· 2 shared Yansheng LiuiD· 2 shared Alexander NguyeniD· 1 shared Azime Akçaöz-AlasariD· 1 shared Bünyamin AkgüliD· 1 shared Carlos Andrés Ramírez Parrado· 1 shared Claudio R. AlarcóniD· 1 shared Daniela Villalobos· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersMolecular Biology

Manoj M. PillaiORCID

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2 papers

Recent·Most cited

Molecular BiologyMolecular CellPeer-reviewedJul 31, 2026

METTL3 promotes cell cycle progression via activation of transcriptional elongation.

Azime Akçaöz-Alasar, Yanhua Wang, Hang Li…·Claudio R. Alarcón

The paper shows that METTL3 phosphorylation by CDK1 promotes transcriptional elongation and cell cycle progression through the m6A/7SK/P-TEFb axis.

DOI 10.1016/j.molcel.2026.07.011

humanmetagenomics

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Cancer BiologybioRxivPreprintOct 8, 2025

A Unifying Mechanism for Shared Splicing Aberrations in Splicing Factor Mutant Cancers

Prajwal Chaitanya Boddu, Rahul Roy, Stephan Hütter…·Manoj M. Pillai

This study identifies a shared trans-acting mechanism in splicing factor mutant cancers that drives retained intron (RI) splicing defects through DDR-induced AMPK-AKT imbalance and SRSF1 hypophosphorylation.

DOI 10.1101/2025.10.08.679601

humanbulk RNA-seq

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