Author

Manoj M. Pillai

Yale Cancer CenterORCID 0000-0002-7835-0145Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Prajwal Chaitanya BodduiD· 2 shared Yansheng LiuiD· 2 shared Alexander NguyeniD· 1 shared Azime Akçaöz-AlasariD· 1 shared Bünyamin AkgüliD· 1 shared Carlos Andrés Ramírez Parrado· 1 shared Claudio R. AlarcóniD· 1 shared Daniela Villalobos· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersMolecular Biology

Prajwal Chaitanya BodduORCID

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2 papers

Recent·Most cited

METTL3 promotes cell cycle progression via activation of transcriptional elongation.

Azime Akçaöz-Alasar, Yanhua Wang, Hang Li, Denis Ostapenko, Carlos Andrés Ramírez Parrado, Daniela Villalobos, Hengyi Li, Prajwal Chaitanya Boddu, Alexander Nguyen, Marcelo Pérez-Pepe, Pénélope Darnat, Bünyamin Akgül, Manoj M. Pillai, Yansheng Liu, Lilian Kabeche, Claudio R. Alarcón

The paper shows that METTL3 phosphorylation by CDK1 promotes transcriptional elongation and cell cycle progression through the m6A/7SK/P-TEFb axis.

Molecular Cell · Jul 31, 2026Peer-reviewedMolecular Biology

A Unifying Mechanism for Shared Splicing Aberrations in Splicing Factor Mutant Cancers

Prajwal Chaitanya Boddu, Rahul Roy, Stephan Hütter, Francis Baumgartner, Wenxue Li, Gabriele Todisco, Francesca Ficara, Matteo Giovanni Della Porta, Yansheng Liu, Torsten Haferlach, Manoj M. Pillai

This study identifies a shared trans-acting mechanism in splicing factor mutant cancers that drives retained intron (RI) splicing defects through DDR-induced AMPK-AKT imbalance and SRSF1 hypophosphorylation.

bioRxiv · Oct 8, 2025 · PreprintCancer Biology