Hugh Wilson

This study uses ABEL-FRET to map RNA structural changes during Cas9 RNP assembly, revealing how guide RNA flexibility is modulated through different assembly states.

This paper develops a Bayesian framework to model radiation damage in cryo-EM datasets by inferring atomic displacements and structural changes during electron irradiation.

This paper introduces a Bayesian method to estimate atomic scattering factors from cryo-EM data, improving accuracy by incorporating molecular environment effects.