Patient-derived monoclonal anti-HPA-1a can induce platelet activation through FcγRIIa
Janita J. Oosterhoff, Suze Rosanne van Brummelen, Marco Giulini, Iris M. De Cuyper, Remco Visser, Rick Kapur, Christoph Gstöttner, Elena Domínguez‐Vega, Thijs W. de Vos, Suzanne Hofstede‐van Egmond, Mark Steven Cragg, Manfred Wuhrer, Leendert Porcelijn, Masja de Haas, Alexandre M. J. J. Bonvin, , Gestur Vidarsson
The paper characterizes two anti-HPA-1a antibodies from a severe FNAIT case, showing functional differences in platelet activation through FcγRIIa engagement.
bioRxiv · Sep 17, 2026 · PreprintImmunology