C. Ellen van der Schoot

Patient-derived monoclonal anti-HPA-1a can induce platelet activation through FcγRIIa

The paper characterizes two anti-HPA-1a antibodies from a severe FNAIT case, showing functional differences in platelet activation through FcγRIIa engagement.

High-resolution cryo-EM structure of integrin αIIbβ3 bound to disease-causing maternal HPA-1a antibody that blocks integrin activation

This study presents the high-resolution cryo-EM structure of integrin αIIbβ3 bound to an anti-HPA-1a antibody, revealing how it blocks integrin activation and platelet aggregation.