Activating the CXCR3/CXCL10 pathway overrides tumor immune suppression by enhancing immune trafficking and effector cell priming in head and neck squamous cell carcinoma
Cheyanne K. Shinn, Robert Saddawi‐Konefka, Catherina L. Salanga, Shiruyeh Schokrpur, Jorge Silvio Gutkind, Tracy M. Handel
This study shows that delivering CXCL10 into tumors enhances immune cell infiltration, activation, and anti-tumor responses, and improves the effectiveness of immunotherapy in head and neck squamous cell carcinoma.
bioRxiv · Apr 24, 2025 · PreprintCancer Biology