Shiyu Jason Jiang

SMARTFlexDB links ligand-bound and ligand-free RNA structures to study conformational flexibility and small-molecule recognition, providing a resource for RNA-targeted drug discovery.

ProTrek introduces a tri-modal contrastive learning model for protein sequence, structure, and function, achieving significant improvements in speed and accuracy over existing tools.

SMARTBind uses deep learning and contrastive learning to identify small molecule binders to RNA without structural input, outperforming existing methods and reducing computational cost.