BiochemistryACS Chemical BiologyPeer-reviewed
Small Molecule Degradation of the microRNA-21 Precursor Rescues Pathogenic Pathways in Cellular Models of Fibrosis
Tenghui Wang, Xueyi Yang, Yeongju Lee…·Matthew David Disney
This study shows that degrading the miR-21 precursor with TGP-21-RiboTAC reduces pathogenic pathways in fibrosis models by reactivating tumor suppressor genes.
DOI 10.1021/acschembio.5c00979