Author

Wei Zhang

Shandong UniversityORCID 0000-0001-9459-680XUnclaimed ORCID profile · follow to get notified of new preprints

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Wei Zhang39 papers · Chinese Academy of Sciences

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2

Frequent Co-Authors

Jiawei GuoiD· 2 shared Moli Sang· 2 shared Shengying LiiD· 2 shared Binju WangiD· 1 shared Bo HuiD· 1 shared Ce GengiD· 1 shared Chaofan Yang· 1 shared Fangyuan ChengiD· 1 shared

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2024-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

Jiawei GuoORCID

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2 papers

Recent·Most cited

BiochemistryJournal of the American Chemical SocietyPeer-reviewedJun 20, 2025

Deciphering the thiolactonization mechanism in thiolactomycin biosynthesis

Jiawei Guo, Qiaoyu Zhang, Yang Shen…·Xingwang Zhang

This paper identifies the enzymatic mechanism for forming the gamma-thiolactone ring in thiolactomycin biosynthesis, revealing the roles of TlnCCy and TlnA.

11 citationstop 3%

experimental assay

BiochemistrybioRxivPreprintMay 3, 2024

Glutamate (E299) is a key residue in the evolutionarily divergence of the SAM-dependent methyltransferases DnrK and RdmB in anthracycline biosynthesis

Moli Sang, Qingyu Yang, Jiawei Guo…·Wei Zhang

The paper identifies residue E299 as critical for the divergent catalytic functions of DnrK and RdmB in anthracycline biosynthesis, revealing distinct mechanisms for 10-hydroxylation and 4-O-methylation.

DOI 10.1101/2024.05.03.592356

experimental assay