BiochemistrybioRxivPreprint
Glutamate (E299) is a key residue in the evolutionarily divergence of the SAM-dependent methyltransferases DnrK and RdmB in anthracycline biosynthesis
Moli Sang, Qingyu Yang, Jiawei Guo…·Wei Zhang
The paper identifies residue E299 as critical for the divergent catalytic functions of DnrK and RdmB in anthracycline biosynthesis, revealing distinct mechanisms for 10-hydroxylation and 4-O-methylation.
DOI 10.1101/2024.05.03.592356