Enzymatic degradation of RNA causes widespread protein aggregation in cell and tissue lysates
Johan Aarum, Claudia Cabrera, Tania A Jones, Shiron Rajendran, Rocco Adiutori, Gavin Giovannoni, Michael R. Barnes, Andrea Malaspina, Denise Sheer
The paper shows that RNA prevents protein aggregation in cell lysates, and that RNA degradation leads to protein aggregation, with specific RNA structures being effective in maintaining protein solubility.
EMBO Reports · Sep 18, 2020Peer-reviewedMolecular Biology