ROCK inhibitor Ripasudil reduces Alzheimer pathological proteins and enhances cellular bioenergetics
Yuehan Li, Zhiqing Liu, Xavier Cambi…·Weiming Xia
This study shows ripasudil reduces tau pathology and improves mitochondrial function in AD models.
Author
Boston UniversityORCID 0000-0001-9497-8701Unclaimed ORCID profile · follow to get notified of new preprints
8 papers
Recent·Most cited
Yuehan Li, Zhiqing Liu, Xavier Cambi…·Weiming Xia
This study shows ripasudil reduces tau pathology and improves mitochondrial function in AD models.
Jordan C. Langston, Alec Candib, Manveen K. Sethi…·Joseph Zaia
This study quantifies matrisome proteins and their post-translational modifications in kidney tubulointerstitium from human biopsies to understand interstitial fibrosis and tubular atrophy progression.
Alan Wacquiez, Hicham Hboub, D. W. Chen…·Mohsan Saeed
This study identifies LSM14A's role in antiviral immunity independent of its localization to P-bodies and peroxisomes, revealing a specialized interaction network that enhances innate immune signaling.
Austin J Rivera, Jou-Hsuan Roxie Lee, Shruti Gupta…·Nelson C. Lau
The paper identifies Traffic Jam as a transcription factor regulating the Flam piRNA cluster and Piwi pathway to suppress transposons and maintain Drosophila fertility.
William E. Hackett, Deborah K. Chang, Luis Eduardo Carvalho, Joseph Zaia
RAMZIS is an R package that improves the interpretation of glycoproteomics data by assessing the significance of glycosylation changes using similarity metrics and quality evaluation.
Joshua Klein, Luis Eduardo Carvalho, Joseph Zaia
The paper improves N-glycopeptide identification using fragmentation prediction and glycome network smoothing, demonstrating performance gains on existing datasets.
The paper demonstrates the use of GlycReSoft to analyze site-specific glycosylation of the SARS-CoV-2 spike protein from glycoproteomics data.
Zhengliang L. Wu, Anthony D. Person, Matthew Anderson…·Robert Sackstein
The paper develops a method to specifically image glycan structures like HS and T/Tn antigens using glycosyltransferases and click chemistry in mesenchymal stem cells and HUVEC cells.