Mohsan Saeed

The paper shows that male and female mice achieve similar protection against a different SARS-CoV-2 strain through distinct immune mechanisms, with sex-specific roles for T-cells and inflammation.

The paper shows eIF4E3 enables efficient translation of viral mRNAs with short 5' UTRs, unlike the canonical eIF4E1, and identifies this as a mechanism used by viruses like VSV to bypass host translation suppression.

This study identifies LSM14A's role in antiviral immunity independent of its localization to P-bodies and peroxisomes, revealing a specialized interaction network that enhances innate immune signaling.

The paper shows that eIF4G cleavage products can either rescue or repress translation, revealing the closed-loop mRNP's role in translational silencing rather than initiation.

This study identifies mAbs targeting HCoV-HKU1 spike protein and shows that receptor-binding site recognition alone does not predict neutralization in primary cells.

This paper introduces a proteogenomic framework combining genetic perturbations and proteomics to map phospho-signaling pathways in primary human T cells, validated with inflammatory stimuli.

This study uses human stem cell-derived alveolar type 2 cells to model SARS-CoV-2 infection, revealing rapid inflammatory responses and drug efficacy against the virus.