Nelson C. Lau

This study identifies Traffic jam as a master regulator of the somatic piRNA pathway in Drosophila ovaries, showing its role in controlling piRNA factors and the flamenco cluster.

The paper identifies Traffic Jam as a transcription factor regulating the Flam piRNA cluster and Piwi pathway to suppress transposons and maintain Drosophila fertility.

The paper quantifies transposable element RNA dynamics in aging human and mouse brains and neurodegenerative diseases, finding age-related changes and disease-specific TE RNA dysregulation.

The paper validates TE insertions from RNAseq data in Drosophila brain transcriptomes and finds that only a minority of predicted insertions are confirmed by PCR, with gene expression differences observed in TE-containing genes.

The paper identifies novel persistent viruses in Aedes aegypti mosquitoes using small RNA sequencing and confirms their replication and transmissibility in cell lines.

This study identifies Myc dysregulation in macrophages as a driver of TB susceptibility by linking lipid peroxidation and IFN-I pathway hyperactivity.

The paper develops an integrated resource to analyze small RNA profiles in mosquitoes, revealing evolutionary dynamics and host responses to viruses and transposons.

The paper quantifies transposable element landscapes in aging Drosophila and shows RNAi mechanisms buffer TE expansion despite increased TE expression.

The paper identifies a truncated P-element variant, Har-P, as the cause of severe gonadal dysgenesis in Drosophila when transmitted paternally, showing its susceptibility to piRNA repression.

This study shows that depletion of RdRP-produced siRNAs in C. elegans leads to ectopic elevation of noncoding RNAs and silencing chromatin marks, and suggests enhancer small RNAs guide H3K9 methylation.