Tumor-associated macrophages confer resistance to chemotherapy (Trifluridine/Tipiracil) in digestive cancers by overexpressing Thymidine Phosphorylase
Marie Malier, Marie‐Hélène Laverrière, Maxime Henry, Malika Yakoubi, Pascale Bellaud, Cécile Arellano, Anthony Sébillot, Fabienne Thomas, Véronique Josserand, Édouard Girard, Gaël S. Roth, Arnaud Millet
The paper shows that tumor-associated macrophages overexpress thymidine phosphorylase, leading to resistance to TAS-102 chemotherapy in digestive cancers.
Cancer Letters · Oct 23, 2024Peer-reviewedPathology