This study evaluates gold nanocluster-functionalized nanoliposomes under orthovoltage X-ray irradiation for enhanced radiotherapy in pancreatic cancer, showing increased reactive oxygen species but challenges in formulation.

Advanced Materials Interfaces · Feb 18, 2026Peer-reviewedBioengineering

Sperm motility restoration in mice suffering from oligo-astheno-teratozoospermia by in vivo injection and electroporation of naked mRNA

Charline Vilpreux, Paul Fourquin, Guillaume Martinez, Magali Court, Florence Appaix, Jean-Luc Duteyrat, Maxime Henry, Julien Vollaire, Camille Ayad, Altan Yavuz, Geneviève Chevalier, Lisa De Macedo, Sofia Andrade Rebelo, Edgar Del Llano, Célia Tebbakh, , Jessica Escoffier

This study uses in vivo mRNA electroporation to restore sperm motility in ARMC2-deficient mice, demonstrating a potential treatment for male infertility.

eLife · Feb 17, 2026Peer-reviewedMolecular Biology

Tumor-associated macrophages confer resistance to chemotherapy (Trifluridine/Tipiracil) in digestive cancers by overexpressing Thymidine Phosphorylase

Marie Malier, Marie‐Hélène Laverrière, Maxime Henry, Malika Yakoubi, Pascale Bellaud, Cécile Arellano, Anthony Sébillot, Fabienne Thomas, Véronique Josserand, Édouard Girard, Gaël S. Roth, Arnaud Millet

The paper shows that tumor-associated macrophages overexpress thymidine phosphorylase, leading to resistance to TAS-102 chemotherapy in digestive cancers.

Cancer Letters · Oct 23, 2024Peer-reviewedPathology