Matthew N. Gaynes

This paper investigates the mechanism of avermitilol synthase, revealing how trapped water molecules influence product specificity through structural and enzymological studies.

The paper reports the cryo-EM structure of a fungal class II terpene synthase cyclase domain and shows substrate channeling between its prenyltransferase and cyclase functions.

This study reports the crystal structure and mechanism of AsDMS, a bifunctional terpene cyclase-phosphatase, revealing its unique dual activity and substrate promiscuity.