Thomas J. C. Sauters

This study compares phenotypic, metabolomic, and genomic variation between two Aspergillus species to determine factors distinguishing opportunistic pathogens from non-pathogens.

The paper links fungal secondary metabolites to their biosynthetic gene clusters using genomic and chemical similarity, identifying 22 known pairs and hypothesizing 38 others in Aspergillus fischeri.

The paper analyzes genomic data from 250 Aspergillus flavus isolates to show that pathogenicity is strongly linked to population structure, with population D containing most clinical isolates and harboring genes related to zinc ion binding and lipid metabolism.

This study examines strain variation in a non-pathogenic fungus, identifying factors linked to virulence differences across strains.

The paper tests the accidental pathogen hypothesis by identifying a QTL linked to amoeba resistance and melanization in Cryptococcus species, finding no correlation with macrophage resistance or virulence.