Jiexin Zhang

This study clarifies that NOTCH1 acts as a tumor suppressor in head and neck cancer, reducing cancer stem cells and improving prognosis, despite conflicting prior reports.

The paper investigates how anti-cancer immunity evolves from preneoplasia to invasive lung adenocarcinomas, identifying changes in immune response and molecular features that may facilitate immune evasion.

This study examines genomic and TCR repertoire heterogeneity in SCLC, finding that lower TCR heterogeneity and mutational burden correlate with better survival.

The paper introduces OBIF, a systems model that identifies molecular drivers of synergy by integrating statistical and biological interactions from omics data.