Midkine Drives Reawakening of Dormant Melanoma Metastases
Carolina Rodríguez-Tirado, Thoufiqul Alam Riaz, Alcina A. Rodrigues, Nupura Kale, Ayax Pérez-Gallegos, David Olmeda, Marı́a S. Soengas, María Soledad Sosa
This paper identifies Midkine as a factor that disrupts melanoma dormancy by suppressing NR2F1 and altering signaling pathways, showing that targeting both Midkine and NR2F1 can limit metastasis and extend survival in mouse models.
bioRxiv · May 27, 2025 · PreprintCancer Biology