Nupura Kale

Base-editing a single missense mutation in A20 enhances CAR-T cell efficacy

This study uses base-editing to inactivate a missense mutation in A20ZF7, enhancing CAR-T cell efficacy by reducing exhaustion and improving anti-tumor responses.

In vivo genome-wide CRISPR screens in human T cells to enhance T cell therapy for solid tumors

This paper performs in vivo CRISPR screens in human T cells to identify genetic modifiers of T cell function in solid tumors, finding P2RY8-G13 and GNAS as key regulators.

Midkine Drives Reawakening of Dormant Melanoma Metastases

This paper identifies Midkine as a factor that disrupts melanoma dormancy by suppressing NR2F1 and altering signaling pathways, showing that targeting both Midkine and NR2F1 can limit metastasis and extend survival in mouse models.

Cellular behavior analysis from live-cell imaging of TCR T cell-cancer cell interactions

The paper develops tools for analyzing T cell behavior from live-cell imaging to improve T cell therapies by studying the effects of genetic modifications on T cell-cancer cell interactions.