Charles C. Bascom

The paper shows that while senescent cells contribute to collagen degradation with age, reduced collagen production in adult skin is due to senescence-independent processes.

This study uses microarray profiling to analyze gene expression changes in human skin after ablative fractional laser treatment, showing gene expression reverses aging-related changes and requires multiple treatments for maximal rejuvenation.

The paper identifies C2orf69 deficiency as a cause of a fatal auto-inflammatory syndrome in humans and zebrafish, affecting mitochondrial function and immune/cNS development.

This paper describes a computational multiscale multicellular skin model that integrates various modeling styles to simulate barrier formation and response to perturbations.