Robert J. Isfort

The paper shows that while senescent cells contribute to collagen degradation with age, reduced collagen production in adult skin is due to senescence-independent processes.

This study uses microarray profiling to analyze gene expression changes in human skin after ablative fractional laser treatment, showing gene expression reverses aging-related changes and requires multiple treatments for maximal rejuvenation.

The paper evaluates synergistic effects of peptide combinations on skin cell regeneration and links these effects to gene expression changes similar to those induced by fractional laser treatment.

The paper identifies C2orf69 deficiency as a cause of a fatal auto-inflammatory syndrome in humans and zebrafish, affecting mitochondrial function and immune/cNS development.

This paper describes a computational multiscale multicellular skin model that integrates various modeling styles to simulate barrier formation and response to perturbations.