Ajay Sriram Mathuru

Modular fluidic automation platform with integrated thermal control for multi-step molecular imaging workflows

This paper introduces two open-source robots for automated multi-step mRNA imaging workflows, enabling precise buffer exchanges, temperature control, and scalable execution of multiplex-FISH experiments.

chrna3 modulates alcohol response in zebrafish

This study investigates the role of chrna3 in alcohol response using zebrafish, finding that chrna3 mutants show increased alcohol tolerance and altered behavior.

Role of chrna5 in multi-substance preference and phenotypes comorbid with the development of substance dependence

This study shows that chrna5 mutations in zebrafish increase preference for nicotine and alcohol and alter behavior and physiology related to substance dependence.

A spatial mRNA profiling workflow using Rapid Amplified Multiplex FISH (RAMFISH)

The paper introduces RAMFISH, a workflow for spatial mRNA profiling in tissues, and validates it on butterfly and zebrafish samples.

Loss of IVNS1ABP, a gigaxonin paralogue, leads to a progeroid neuropathy due to impaired proteostasis

This study shows that loss of IVNS1ABP causes a progeroid neuropathy by impairing proteostasis, leading to protein aggregation and lysosomal dysfunction in neuronal cells.

Evaluating the transmission risk of amyloid beta peptide via ingestion

This study investigates whether human amyloid beta aggregates can be transmitted via ingestion across species using zebrafish and Drosophila models, finding no detectable transmission or pathology.

Oxytocin receptors influence the development and maintenance of social behavior in zebrafish (Danio rerio).

This study shows that oxytocin receptors influence the development and maintenance of social behavior in zebrafish, with effects varying by age and social context.

Contingent-behavior assay to study the neurogenetics of addiction shows zebrafish preference for alcohol is biphasic

The paper develops a zebrafish assay to study alcohol preference, finding a biphasic response where low alcohol concentrations are attractive and high concentrations are avoided.

Loss of C2orf69 defines a fatal auto-inflammatory mitochondriopathy in Humans and Zebrafish

The paper identifies C2orf69 deficiency as a cause of a fatal auto-inflammatory syndrome in humans and zebrafish, affecting mitochondrial function and immune/cNS development.

Neural correlates of state transitions elicited by a chemosensory danger cue

The paper investigates neural circuits in zebrafish larvae responding to a chemosensory danger cue, identifying brain regions involved in state transitions and their potential role in stress-related disorders.

Computational geometric tools for modeling inherent variability in animal behavior

The paper introduces two computational geometric methods to analyze and compare behavioral variability in medaka fish, showing that alarmed fish exhibit less predictable swimming despite shared action patterns.

Application of Optogenetic Amyloid-β Distinguishes Between Metabolic and Physical Damage in Neurodegeneration

This study uses optogenetic Amyloid-β to distinguish between metabolic and physical damage in Alzheimer's disease, showing that oligomerization causes severe tissue loss and that Li+ treatment reduces lifespan deficits.

Familiarity with companions aids recovery from fear inzebrafish

This study shows that zebrafish recover from fear more effectively when with familiar companions, as evidenced by reduced fear behaviors, lower cortisol, and increased isotocin.