Klaas Jan van Wijk

This study investigates the role of CLPD in chloroplast proteostasis by analyzing its expression, developmental effects, and interactions with the CLP protease core and candidate substrates in Arabidopsis.

The paper investigates the role of the chloroplast CLP system in regulating the steady-state levels of EX1 and EX2, finding that CLP degradation maintains their low concentrations before their 1O2 signaling function.

This study identifies loss of FMT as a suppressor of clpc1 mutant defects, revealing mitochondrial perturbation enables nuclear reprogramming to restore chloroplast proteostasis.

This paper reports the first high-resolution cryo-EM structures of an S9D protease, revealing its dimerization mechanism, catalytic regulation, and substrate selectivity through hinge-loop gating and conserved glutamate pocket.

The paper identifies DUF760-1 and DUF760-2 as substrates of the chloroplast CLP protease system, showing they have distinct degradation rates and functional roles.