Jacqueline J. Ehrlich

This paper reports the first high-resolution cryo-EM structures of an S9D protease, revealing its dimerization mechanism, catalytic regulation, and substrate selectivity through hinge-loop gating and conserved glutamate pocket.

This paper identifies the C-terminal activating domain (CAD) as essential for Panx1 channel opening, showing how its cleavage repositions the N-terminus to reduce anion accumulation and promote ion permeability.