NeurosciencebioRxivPreprint
G protein-biased LPAR1 agonism promotes prototypic antidepressant effects
Naoto Kajitani, Mami Okada‐Tsuchioka, Asuka Inoue…·Minoru Takebayashi
This study identifies G protein-biased LPAR1 agonism as a mechanism underlying the antidepressant effects of TCAs like amitriptyline, distinguishing them from SSRIs.
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