A systems genomics approach uncovers molecular associates of RSV severity
Matthew N. McCall, Chin‐Yi Chu, Lu Wang…·Thomas J. Mariani
The paper integrates multi-omic data to identify cellular pathways associated with RSV severity in infants.
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University of Rochester MedicineORCID 0000-0001-9545-0853Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Matthew N. McCall, Chin‐Yi Chu, Lu Wang…·Thomas J. Mariani
The paper integrates multi-omic data to identify cellular pathways associated with RSV severity in infants.
Derick R. Peterson, Andrea M Baran, Soumyaroop Bhattacharya…·Thomas J. Mariani
The paper develops a gene expression risk score to predict severe COVID-19 illness using peripheral blood samples and validates it in independent cohorts.
Chin‐Yi Chu, Xing Qiu, Matthew N. McCall…·Thomas J. Mariani
The paper identifies a lack of airway interferon activation as a marker of severe infant RSV infection and shows that blocking IFN signaling increases viral infection in vitro.