David J. Topham

Single cell analysis of neonatal naïve CD8α+ T cells reveals novel subsets bridging the innate-adaptive spectrum

The paper identifies novel neonatal CD8β+ T cell subsets (FITs) with innate-like features, distinct from conventional and unconventional T cells, using cord blood samples.

Fluximplied: A novel approach integrates rate limiting steps and differential expression for pathway analysis

A systems genomics approach uncovers molecular associates of RSV severity

The paper integrates multi-omic data to identify cellular pathways associated with RSV severity in infants.

Insufficiency in airway interferon activation defines clinical severity to infant RSV infection

The paper identifies a lack of airway interferon activation as a marker of severe infant RSV infection and shows that blocking IFN signaling increases viral infection in vitro.

Highly Efficient Hypothesis Testing Methods for Regression-type Tests with Correlated Observations and Heterogeneous Variance Structure

The paper introduces efficient hypothesis testing methods for regression-type tests with correlated data and heterogeneous variance, outperforming existing methods in speed and accuracy.

Neonate gut and respiratory microbiota: coordinated development through time and space

The paper examines co-occurrence patterns of gut and respiratory microbiota in pre- and full-term infants over the first year, identifying three patterns of CST manifestation related to infant maturity.