Thomas J. Mariani

This study shows that SARS-CoV-2 defective viral genomes from different genomic hotspots induce divergent interferon responses, with hotspot B DVGs strongly stimulating IFN responses and hotspot A DVGs not.

This study investigates how environmental olfactory exposures affect cell-type specific transcriptional responses in the mouse main olfactory epithelium using single-cell RNA sequencing.

This study uses single-cell RNA sequencing to analyze age and cell population-specific responses to SARS-CoV-2 infection in lung epithelial cells, identifying differences in innate immune signaling between pediatric and adult tissues.

The paper uses single-cell RNA sequencing to create a molecular map of newborn human lung cells and identifies cell type-specific developmental states and biomarkers.

This study creates a single-cell atlas of prenatal Trisomy 21 lungs, revealing molecular changes linked to early pulmonary complications.

The paper integrates multi-omic data to identify cellular pathways associated with RSV severity in infants.

The paper develops a gene expression risk score to predict severe COVID-19 illness using peripheral blood samples and validates it in independent cohorts.

The paper identifies gene expression patterns in CD8+ T cells associated with BPD and PRD in preterm infants using transcriptomic data from the PROP cohort.

The paper identifies a lack of airway interferon activation as a marker of severe infant RSV infection and shows that blocking IFN signaling increases viral infection in vitro.