Author

Daren Liu

Regeneron (United States)ORCID 0000-0001-9551-8854Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 3 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:database / resource· 2 Approach:experimental assay· 2 Research Focus:GWAS / association mapping· 2 Approach:statistical model· 2 Assay:whole-exome sequencing· 2 Assay:electronic health records· 1 Assay:GWAS summary statistics· 1

Frequent Co-Authors

Jeffrey C. StaplesiD· 4 shared Alan R. ShuldineriD· 3 shared Alicia C. Hawes· 3 shared Aris N. EconomidesiD· 3 shared Cristopher V. Van HoutiD· 3 shared Evan K. MaxwelliD· 3 shared Giovanni CoppolaiD· 3 shared Gonçalo R. AbecasisiD· 3 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersGenetic & Genomic Medicine

Jeffrey C. StaplesORCID

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4 papers

Recent·Most cited

Genetic & Genomic MedicineNature GeneticsPeer-reviewedMar 3, 2022

Genome-wide analysis in 756,646 individuals provides first genetic evidence that ACE2 expression influences COVID-19 risk and yields genetic risk scores predictive of severe disease

Julie E. Horowitz, Jack A. Kosmicki, Amy Damask…·Arden Moscati

The paper identifies a rare variant that lowers ACE2 expression and reduces COVID-19 risk, and develops a genetic risk score predicting severe disease.

202 citationstop 1%

humanGWAS summary statistics

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Genetic & Genomic MedicineNature GeneticsPeer-reviewedJun 28, 2021

Advancing Human Genetics Research and Drug Discovery through Exome Sequencing of the UK Biobank

Joseph D. Szustakowski, Suganthi Balasubramanian, Erika M. Kvikstad…·Adam Platt

The paper describes exome sequencing of 200,643 UK Biobank participants, providing a rich resource of coding variants for genetic and drug discovery research.

401 citationstop 1%

humanwhole-exome sequencing

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Genetic & Genomic MedicinemedRxivPreprintMay 31, 2021

Genomic analyses in a large clinical cohort reveal high prevalence of MECP2 variants associated with neuropsychiatric phenotypes in adulthood

Claudia G. Gonzaga-Jauregui, Alina Kurolap, Lauren Walsh…·Christa Lese Martin

The paper was withdrawn due to lack of full author consent.

DOI 10.1101/2021.05.31.21257498

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GenomicsbioRxivPreprintMar 9, 2019

✦ In-depth digest

Whole exome sequencing and characterization of coding variation in 49,960 individuals in the UK Biobank

Cristopher V. Van Hout, Ioanna Tachmazidou, Joshua Backman…·Aris Baras

Exomes of 49,960 UK Biobank participants reveal 231,631 predicted loss-of-function variants (>10-fold more than imputed data); burden tests implicate PIEZO1, MEPE, and COL6A1 in disease traits.

110 citations

humanwhole-exome sequencing

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