Vincent Giguère

The paper identifies ERRα and ERRγ as regulators of cold-induced GPR3 expression in adipocytes, showing their role in thermogenic energy expenditure.

The paper identifies Esrra as a master regulator of adaptive hepatic translation during prolonged starvation by inducing Rplp1 expression and lysosome/autophagy protein translation.

The paper identifies 48 new transcriptional interactors of ERRα in mouse liver, including HCFC1, revealing a regulatory network controlling oxidative phosphorylation.

This study identifies Esrra's role in regulating Rplp1-mediated translation of lysosomal and autophagy proteins during NASH, showing that alternate day fasting can reverse these effects.