Cairong Yang

This study shows DAZL regulates maternal mRNA translation in oocytes by both repressing and activating specific transcripts during maturation.

The paper uses RiboTag/RNA-Seq to show a global switch in maternal mRNA translation during oocyte meiotic resumption, with repression of previously active transcripts and activation of previously repressed ones.

This study shows that CCNB2 is essential for meiotic progression in mouse oocytes, as its absence causes defects in pre-MPF activity, spindle assembly, and meiosis I completion.