Marco Conti

This study identifies CDK1/MAPK and AURKA/PLK1 pathways as converging on CPEB1 phosphorylation during mouse oocyte meiosis, showing CDK1 is critical for translation activation.

This study shows that the Hira complex is essential for oocyte developmental competence by maintaining transcriptional silencing through H3.3 deposition and chromatin modifications.

This study shows DAZL regulates maternal mRNA translation in oocytes by both repressing and activating specific transcripts during maturation.

The paper uses RiboTag/RNA-Seq to show a global switch in maternal mRNA translation during oocyte meiotic resumption, with repression of previously active transcripts and activation of previously repressed ones.

This study shows that CCNB2 is essential for meiotic progression in mouse oocytes, as its absence causes defects in pre-MPF activity, spindle assembly, and meiosis I completion.