Enrico Maria Daldello

Cyclin B phosphorylation by PKA safeguards the G2-arrest in vertebrate oocytes

This study identifies Cyclin B2 as a PKA substrate that phosphorylation at S271 represses Cdk1-Cyclin B activation, maintaining G2-arrest in vertebrate oocytes.

Protein accumulation upstream of Cdk1 activation regulates the competence and the timing of meiosis resumption

The paper shows that protein accumulation upstream of Cdk1 activation regulates meiosis resumption timing and competence in oocytes through stepwise acquisition of regulatory mechanisms.

Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics

This study uses phosphoproteomics to analyze protein phosphorylation during Xenopus oocyte meiotic divisions, revealing key phosphorylation events and their roles in meiotic processes.

Multiple intersecting pathways are involved in the phosphorylation of CPEB1 to activate translation during mouse oocyte meiosis

This study identifies CDK1/MAPK and AURKA/PLK1 pathways as converging on CPEB1 phosphorylation during mouse oocyte meiosis, showing CDK1 is critical for translation activation.

The RNA binding protein DAZL functions as repressor and activator of maternal mRNA translation during oocyte maturation

This study shows DAZL regulates maternal mRNA translation in oocytes by both repressing and activating specific transcripts during maturation.

Genome-wide analysis reveals a switch in the translational program upon oocyte meiotic resumption

The paper uses RiboTag/RNA-Seq to show a global switch in maternal mRNA translation during oocyte meiotic resumption, with repression of previously active transcripts and activation of previously repressed ones.

Cyclin B2 is required for progression through meiosis in mouse oocytes

This study shows that CCNB2 is essential for meiotic progression in mouse oocytes, as its absence causes defects in pre-MPF activity, spindle assembly, and meiosis I completion.